Intermolecular C–H activation by reactive titanocene alkylidene intermediates

SnapShot: Reactive Oxygen Intermediates (ROI)

Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates.

IN THIS ISSUE of AJP-Lung, Kaestle et al. (28) report that an increase in left atrial pressure in isolated perfused lungs induces a Ca -dependent increase of endothelial nitric oxide (NO) production, which decreases reabsorption of fluid across the alveolar epithelium, resulting in pulmonary edema. Furthermore, they report that in chronic heart failure, NO production by endothelial cells is imp...

Haem-oxygen reactive intermediates: catalysis by the two-step.

The catalytic schemes of a variety of haem enzymes, including the P450 mono-oxygenases, consist of a number of common reactive haem-oxygen adducts. The characterization of these intermediates by optical and EPR spectroscopies has reinforced the similarity of these intermediate states in a number of haem enzyme systems. Furthermore, the reactivity of these states in P450 and horseradish peroxida...

Acceleration of nucleophilic CH activation by strongly basic solvents.

(IPI)Ru(II)(OH)(n)(H(2)O)(m), 2, where IPI is the NNN-pincer ligand, 2,6-diimidizoylpyridine, is shown to catalyze H/D exchange between hydrocarbons and strongly basic solvents at higher rates than in the case of the solvent alone. Significantly, catalysis by 2 is accelerated rather than inhibited by increasing solvent basicity. The evidence is consistent with the reaction proceeding by base mo...

Intermolecular arene C-H activation by nickel(II).

Intermolecular arene C-H activation mediated by a divalent nickel species under extremely mild conditions is described. The reactions of either Ni(COD)2 with H[N(o-C6H4PR2)2] (H[R-PNP]; R = iPr, Cy) in benzene at room temperature or [R-PNP]NiCl with LiBHEt3 in THF at -35 degrees C produced the corresponding [R-PNP]NiH in high yield. Addition of 1 equiv of B(C6F5)3 to a benzene solution of [R-PN...